Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Description
Rabbit polyclonal antibody to ASPP2

Applications 
WB.

Immunogen 
ASPP2 Antibody detects endogenous levels of total ASPP2.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Chicken(%), Xenopus(%)

Molecular weight
126kDa; 126kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ASPP2

Synonyms 
53BP2; Apoptosis stimulating of p53 protein 2; Apoptosis stimulating protein of p53 2; Apoptosis-stimulating of p53 protein 2; ASPP2; ASPP2_HUMAN; BBP; Bcl2 binding protein; Bcl2-binding protein; NY REN 51 antigen; p53 binding protein 2; p53-binding protein 2; p53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; Tp53bp2; Tumor protein p53 binding protein 2; Tumor suppressor p53 binding protein 2; Tumor suppressor p53-binding protein 2;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q13625

Western blot analysis of extracts from NIH-3T3 cells, using ASPP2 Antibody. The lane on the left was treated with blocking peptide....

Western blot analysis of extracts from Jurkat , using ASPP2 Antibody. The lane on the left was treated with blocking peptide....

Western blot analysis of extracts from various samples, using ASPP2 Antibody. Lane 1: Hepg2 cells(h2o2 treatment), blocked with antigen-specific peptides. Lane 2: Hepg2 cells(h2o2 treatment). Lane 3: Raw264.7 cells(uv treatment)....