Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Description
Rabbit polyclonal antibody to ASIP

Applications 
WB.

Immunogen 
ASIP Antibody detects endogenous levels of total ASIP.

Reactivity 
Human.
可预测：Bovine(100%), Horse(%), Sheep(%), Dog(%)

Molecular weight
14 kDa; 15kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ASIP

Synonyms 
agouti signaling protein; Agouti switch protein; AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
P42127

Western blot analysis of ASIP using 293 whole lysates....