Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.

Description
Rabbit polyclonal antibody to ARRDC3

Applications 
WB, IF, ICC.

Immunogen 
ARRDC3 Antibody detects endogenous levels of total ARRDC3.

Reactivity 
Human, Mouse, Rat.
可预测：Bovine(91%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Chicken(%)

Molecular weight
46 KD; 46kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ARRDC3

Synonyms 
ARRDC 3; Arrestin domain containing 3; Arrestin domain containing protein 3; KIAA1376; TBP-2-like inducible membrane protein; Thioredoxin binding protein 2 like inducible membrane; TLIMP;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q96B67

Western blot analysis of extracts from 293 and mouse brain, using ARRDC3 Antibody....

ab14377 staining A549 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with primary Ab(ab14377) and mouse anti-beta tubulin for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody. The nuclear counter stain is DAPI (blue)....