Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

Description
Rabbit polyclonal antibody to ARPC1B

Applications 
WB.

Immunogen 
ARPC1B Antibody detects endogenous levels of total ARPC1B.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Zebrafish(%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Chicken(%)

Molecular weight
41 kDa; 41kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ARPC1B

Synonyms 
Actin related protein 2/3 complex subunit 1B 41kDa; Actin related protein 2/3 complex subunit 1B; Actin-related protein 2/3 complex subunit 1B; ARC1B_HUMAN; ARC41; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; Arpc1b; p40 ARC; p41 ARC; p41-Arc;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
O15143

Western blot analysis of extracts from Human breast cancer tissue, using ARPC1B Antibody. The lane on the left was treated with blocking peptide....