Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

Description
Rabbit polyclonal antibody to AQP3

Applications 
WB, IHC.

Immunogen 
AQP3 Antibody detects endogenous levels of total AQP3.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Xenopus(%)

Molecular weight
31 kDa(glyco AQP3~ 45kd); 32kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
AQP3

Synonyms 
AQP 3; AQP-3; Aqp3; AQP3_HUMAN; Aquaglyceroporin-3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); Aquaporin-3; Aquaporin3; GIL; Gill blood group;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q92482

Western blot analysis of extracts from PC12, using AQP3 Antibody. The lane on the left was treated with blocking peptide....

ab11015 at 1/100 staining Human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody....

ab11015 at 1/100 staining Human colorectal cancer by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

ab11015 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

ab11015 at 1/100 staining Mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

ab11015 at 1/100 staining Rat kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

Fig. 1. |Expression of AQP3 protein in the placenta (I, II) and fetal membranes (III, IV) shown in IHC and (I, III)Western blotting (I, IV) images....

Fig. 1. |Expression of AQP3 protein in the placenta (I, II) and fetal membranes (III, IV) shown in IHC and (I, III)Western blotting (I, IV) images....

Figure 3. Daidzein increased lipopolysaccharide (LPS)-induced downregulated expression of tight junction and AQP3 proteins and mRNA. (A) The protein expression levels of ZO-1 and occludin and protein quantitative analysis. (B) The protein expression levels of claudin-1 and AQP3 and protein quantitative analysis. (C–F) The mRNA expression levels of ZO-1, occludin, claudin-1, and AQP3 (mean ± SD, n = 3), * p < 0.05, ** p < 0.01, and *** p < 0.001 versus LPS-treated alone. # p < 0.05, ## p < 0.01, and ### p < 0.001 versus control....