DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.

Description
Rabbit polyclonal antibody to APOBEC3G

Applications 
WB, IHC.

Immunogen 
APOBEC3G Antibody detects endogenous levels of total APOBEC3G.

Reactivity 
Human.
可预测：Mouse(%)

Molecular weight
58 KD; 59kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
APOBEC3G 

Synonyms 
A3G; ABC3G_HUMAN; APOBEC related cytidine deaminase; APOBEC related protein; APOBEC-related cytidine deaminase; APOBEC-related protein 9; APOBEC-related protein; APOBEC3G; Apolipoprotein B editing enzyme catalytic polypeptide like 3G; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; Apolipoprotein B mRNA editing enzyme catalytic subunit 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15; CEM15; deoxycytidine deaminase; dJ494G10.1; DNA dC dU editing enzyme APOBEC 3G; DNA dC->dU editing enzyme; DNA dC->dU-editing enzyme APOBEC-3G; EC 3.5.4.; FLJ12740; MDS019; OTTHUMP00000028911; phorbolin-like protein; phorbolin-like protein MDS019;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q9HC16
 

Western blot analysis of extracts from Mouse testis, using APOBEC3G Antibody at 1/1000 dilution. Observed bands:50kD....

ab16476 at 1/100 staining Human heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody....