DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Description
Rabbit polyclonal antibody to APOBEC3D/F

Applications 
WB, IF, ICC, IHC.

Immunogen 
APOBEC3D/F Antibody detects endogenous levels of total APOBEC3D/F.

Reactivity 
Human, Rat.

Molecular weight
40 KD; 47kD,45kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
APOBEC3D/F 

Synonyms 
A3D; ABC3D_HUMAN; APOBEC3D; APOBEC3DE; APOBEC3E; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3D; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3E pseudogene; ARP6; bK150C2.9; BK150C2.9 protein; DNA dC >dU editing enzyme APOBEC 3D; DNA dC->dU-editing enzyme APOBEC-3D; hCG_41704; HCG41704, isoform CRA_b; Probable DNA dC->dU-editing enzyme APOBEC-3D; Apolipoprotein B mRNA editing enzyme, catalytic polypeptide like 3F; ARP8; DNA dC->dU-editing enzyme APOBEC-3F; Induced upon T cell activation; KA6;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q96AK3 | Q8IUX4

ab15191 at 1/100 staining Rat lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody....