Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A.

Description
Rabbit polyclonal antibody to ALPK1

Applications 
WB, IF, ICC, IHC.

Immunogen 
ALPK1 Antibody detects endogenous levels of total ALPK1.

Reactivity 
Human, Mouse.
可预测：Sheep(88%)

Molecular weight
139 KD; 139kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ALPK1

Synonyms 
8430410J10Rik; Alpha protein kinase 1; Alpha-protein kinase 1; ALPK1; ALPK1_HUMAN; Chromosome 4 kinase; LAK; Lymphocyte alpha kinase; Lymphocyte alpha protein kinase; Lymphocyte alpha-protein kinase; RGD1304613;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q96QP1

ab14271 at 1/100 staining human liver cancer by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody....