Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.

Description
Rabbit polyclonal antibody to ADCY5/6

Applications 
WB, IF, ICC, IHC.

Immunogen 
ADCY5/6 Antibody detects endogenous levels of total ADCY5/6.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)

Molecular weight
138 KD; 139kD,131kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ADCY5/6

Synonyms 
AC 5; AC5; ADCY 5; Adcy5; ADCY5_HUMAN; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5; ATP pyrophosphate lyase 5; ATP pyrophosphate-lyase 5; AC6; ACVI; ADCY 6; Adcy6; ADCY6_HUMAN; ADCYB; Adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate lyase 6; ATP pyrophosphate-lyase 6; Ca(2+) inhibitable adenylyl cyclase; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; EC 4.6.1.1; KIAA0422;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
O95622 | O43306

Fig. 5. |Anxiety disorder correlates with inhibition of AC5 and PKA in liver and expression of inflammatory cytokines in brain. a The protein expression of AC5 and PKA....