Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Description
Rabbit polyclonal antibody to ADCY2

Applications 
WB, IF, ICC.

Immunogen 
ADCY2 Antibody detects endogenous levels of total ADCY2.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(92%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)

Molecular weight
110 kDa; 124kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ADCY2

Synonyms 
3',5' cyclic AMP synthetase; Adenylate cyclase II; AC2; Adenylate cyclase 2 (brain); Adenylate cyclase 2; Adenylate cyclase type 2; Adenylate cyclase type II; ATP pyrophosphate lyase 2; FLJ16822; FLJ45092; HBAC2; KIAA1060; MGC133314; Type II adenylate cyclase;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q08462

Western blot analysis of extracts from Mouse testis, using ADCY2 Antibody at 1/1000 dilution. Observed bands:100kD....

Western blot analysis of extracts from COLO205 cells(heat-shock treatment), using ADCY2 Antibody at 1/1000 dilution. Observed bands:100kD....

ab13240 staining Hela cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with primary Ab(ab13240) and mouse anti-beta tubulin Ab(T0023) for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody. The nuclear counter stain is DAPI(blue)....