The precursor is cleaved by a furin endopeptidase.

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Description
Rabbit polyclonal antibody to ADAMTS18

Applications 
WB, IF, ICC, IHC.

Immunogen 
ADAMTS18 Antibody detects endogenous levels of total ADAMTS18.

Reactivity 
Human, Mouse.
可预测：Pig(100%), Bovine(100%), Horse(100%), Sheep(90%), Rabbit(90%), Dog(100%), Chicken(90%)

Molecular weight
135 KD; 135kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ADAMTS18

Synonyms 
A disintegrin and metalloproteinase with thrombospondin motifs 18; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 18; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 21; ADAM metallopeptidase with thrombospondin type 1 motif 18; ADAM-TS 18; ADAM-TS18; ADAMTS 18; ADAMTS-18; ADAMTS18; ADAMTS21; ATS18_HUMAN; Disintegrin and metalloprotease like protein; EC 3.4.24.; KNO2;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
Q8TE60
 

Western blot analysis of extracts from Mouse testis, using ADAMTS18 Antibody at 1/1000 dilution. Observed bands:130kD....

ab14599 at 1/100 staining Human pancreatic cancer by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

ab14599 at 1/100 staining Human kidney cancer and adjacent normal tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....