Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Description
Rabbit polyclonal antibody to ADA2L

Applications 
WB, IF, ICC.

Immunogen 
ADA2L Antibody detects endogenous levels of total ADA2L.

Reactivity 
Human,Mouse,Rat,Monkey.
可预测：Pig(100%), Zebrafish(91%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(91%)

Molecular weight
47kDa; 52kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ADA2L

Synonyms 
ADA2 ALPHA; ADA2; ADA2 like; ADA2 like protein; ADA2, yeast, homolog of, alpha; ADA2A; hADA2; KL04P; Tada2l; Transcriptional adapter 2 alpha; Transcriptional adapter 2 like; Transcriptional adaptor 2 (ADA2 homolog, yeast) like; Transcriptional adaptor 2 (ADA2, yeast, homolog) like; Transcriptional adaptor 2 alpha; Transcriptional adaptor 2A;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
O75478

Western blot analysis of extracts from various samples, using ADA2L Antibody. Lane 1: Mouse lung lysates; Lane 2: Mouse kidney lysates; Lane 3: Mouse kidney lysates treated with blocking peptide;...