On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

Description
Rabbit polyclonal antibody to ACVR2A

Applications 
WB, IF, ICC, IHC

Immunogen 
ACVR2A Antibody detects endogenous levels of total ACVR2A.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)

Molecular weight
57kDa, 80 kDa; 58kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ACVR2A

Synonyms 
Activin A receptor type IIA;Activin receptor type 2A;Activin receptor type IIA;Activin receptor type-2A;ACTR 2;ACTR IIA;ACTR-IIA;ACTR2;ACTRII;ACTRIIA;Acvr 2;Acvr 2A;Acvr2;ACVR2A;AVR2A_HUMAN;OTTHUMP00000197918;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
P27037

Western blot analysis of extracts from Colo205, using ACVR2A Antibody. The lane on the left was treated with blocking peptide. Observed bands: 80 kDa....

ab16790 at 1/100 staining Human pancreatic cancer and adjacent nomal tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....

ab16790 staining Hela cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with primary Ab(ab16790 1:200) and mouse anti-beta tubulin Ab(T0023 1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody. The nuclear counter stain is DAPI(blue)....

Figure 9 Identification of the miR-192 target gene. (A) Bubble chart indicating the KEGG pathways associated with miR-192 targets. (B) GO enrichment analysis of miR-192 targets. (C) The predicted binding region between miR-192 and Acvr2a mRNA was predicted using bioinformatics analysis. (D) Luciferase activity assay. (E) The mRNA expression of Acvr2a was assessed in GCs transfected with miR-192 mimics via RT-PCR. (F) At 48 h post-transfection, ACVR2A protein level in cultural PGCs was determined via Western blotting. GAPDH expression levels were used to normalize protein levels. Data are presented as means ± SE. (n = 3). ** p < 0.01....