A non-specific tyrosine phosphatase that dephosphorylates a perse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Description
Rabbit polyclonal antibody to ACPP

Applications 
WB, IHC.

Immunogen 
ACPP Antibody detects endogenous levels of total ACPP.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(86%), Bovine(86%), Horse(86%), Sheep(86%), Dog(86%)

Molecular weight
48kDa; 45kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ACPP

Synonyms 
5'-NT; 5'-nucleotidase; Acid phosphatase prostate; ACP 3; ACP3; acpP; Ecto-5'-nucleotidase; PAP; PPAP_HUMAN; Prostatic acid phosphatase; Prostatic acid phosphotase; Thiamine monophosphatase; TMPase;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
P15309
 

Western blot analysis of extracts from MCF-7, using ACPP antibody. The lane on the left was treated with the antigen-specific peptide....

ab16762 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody....