Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.

Description
Rabbit polyclonal antibody to ABCG1

Applications 
WB.

Immunogen 
ABCG1 Antibody detects endogenous levels of total ABCG1.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Zebrafish(83%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(100%)

Molecular weight
110 kDa; 76kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
ABCG1

Synonyms 
ABC transporter 8; ABC8; ABCG1; ABCG1_HUMAN; ATP-binding cassette sub family G member 1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub family G WHITE member 1; homolog of Drosophila white; MGC34313; White protein homolog; White protein homolog ATP binding cassette transporter 8; WHITE1; WHT1;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
P45844

FIGURE 6 Effects of TAN, HxMF, and HpMF on ox-LDL-induced cholesterol efflux (A); effects of TAN, HxMF, and HpMF on mRNA expression of SRB1 and ABCG1 in ox-LDL-treated RAW264.7 cells (B,C); effects of TAN, HxMF, and HpMF on protein expression of SRB1 in ox-LDL-treated RAW264.7 cells (D–F); and effects of TAN, HxMF, and HpMF on protein expression of ABCG1 in ox-LDL-treated RAW264.7 cells (G–I). All experiments were run in triplicate and data showed mean ± SD. ##p < 0.01 compared with the control group, *p < 0.05 and **p < 0.01 compared with the ox-LDL group....