Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity).
Description
Rabbit polyclonal antibody to ABCD1
Applications
WB, IF, ICC, IHC.
Immunogen
ABCD1 Antibody detects endogenous levels of total ABCD1.
Reactivity
Human.
可预测：Pig(89%), Bovine(89%), Horse(89%), Rabbit(89%), Dog(89%)
Molecular weight
75 KD; 83kD(Calculated).
Host species
Rabbit
Ig class
Immunogen-specific rabbit IgG
Purification
Antigen affinity purification
Full name
ABCD1
Synonyms
ABC42; Abcd1; ABCD1_HUMAN; Adrenoleukodystrophy protein; ALD; Aldgh; ALDP; AMN; ATP binding cassette, sub family D (ALD), member 1; ATP-binding cassette sub-family D member 1; OTTHUMP00000025960; OTTMUSP00000019283; RGD1562128; RP23 373N8.2; X linked adrenoleukodystrophy (ALD) gene homolog;
Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Swissprot
P33897
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