G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Description
Rabbit polyclonal antibody to 5HT1F Receptor

Applications 
WB, IF, ICC

Immunogen 
5HT1F Receptor Antibody detects endogenous levels of total 5HT1F Receptor.

Reactivity 
Human, Mouse, Rat.
可预测：Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(82%), Chicken(100%), Xenopus(100%)

Molecular weight
38 KD; 42kD(Calculated).

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Full name 
5HT1F Receptor

Synonyms 
5 HT 1F; 5 HT1F; 5 hydroxytryptamine (serotonin) receptor 1F; 5 hydroxytryptamine 1F receptor; 5 hydroxytryptamine receptor 1E beta; 5 hydroxytryptamine receptor 1F; 5 hydroxytryptamine serotonin receptor 1E beta; 5 hydroxytryptamine serotonin receptor 1F; 5HT 1F; 5HT1F; HGNC5292; HTR 1F; HTR1EB; HTR1EL; HTR1F; MR 77; MR77; Serotonin receptor 1E beta; Serotonin receptor gene;

Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Swissprot 
P30939

Western blot analysis of extracts from mouse lung, using 5-HT-1F antibody....

FIGURE 3 Expression of 5-HT1F receptor in the spinal cord of sham and neuropathic pain rats. (A) The protein level of 5-HT1F receptor was significantly decreased in SNI rats, beginning at day 3 after surgery and remain at low level until day 14 (** p < 0.01 compared with sham group, n = 6 in each group). (B) Histogram showing the mean intensity of 5-HT1F receptor immunofluorescent activity was significantly decreased in SNI rats, beginning at day 3 after surgery and remain at low level until day 14 (****p < 0.0001 compared with sham group, n = 6 in each group). (C–H) Representative photomicrographs showed that neuropathic pain induced the downregulation of 5-HT1F receptor in the spinal cord....

FIGURE 3 Expression of 5-HT1F receptor in the spinal cord of sham and neuropathic pain rats. (A) The protein level of 5-HT1F receptor was significantly decreased in SNI rats, beginning at day 3 after surgery and remain at low level until day 14 (** p < 0.01 compared with sham group, n = 6 in each group). (B) Histogram showing the mean intensity of 5-HT1F receptor immunofluorescent activity was significantly decreased in SNI rats, beginning at day 3 after surgery and remain at low level until day 14 (****p < 0.0001 compared with sham group, n = 6 in each group). (C–H) Representative photomicrographs showed that neuropathic pain induced the downregulation of 5-HT1F receptor in the spinal cord....