产品背景

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in inpiduals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. 

 

Storage 
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Description 
Anti-AFP rabbit polyclonal antibody

Applications 
ELISA, WB, IHC

Immunogen 
Fusion protein of human AFP

Reactivity 
Human

Content 
0.5 mg/ml

Host species 
Rabbit

Ig class 
Immunogen-specific rabbit IgG

Purification 
Antigen affinity purification

Symbol 
AFP

Full name 
alpha fetoprotein

Synonyms 
AFPD; FETA; HPAFP

Swissprot 
P02771

The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ab100020(AFP Antibody) at dilution 1/50. (Original magnification: ×200)...

The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using ab100020(AFP Antibody) at dilution 1/50. (Original magnification: ×200)...

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue lysate, Primary antibody: ab100020(AFP Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds...