产品背景

ZZZ3 (ZZ-type zinc finger-containing protein 3) is a 903 amino acid protein that contains one HTH myb-type DNA-binding domain and one ZZ-type zinc finger. Phosphorylated upon DNA damage by ATM or ATR, ZZZ3 is a subunit of the ATAC complex, which is composed of GCN5, CRP2BP, ADA3, TADA2L, DR1, CCDC101, YEATS2, WDR5 and MBIP. The ATAC complex has histone acetyltransferase activity on histones H3 and H4. ZZZ3 is expressed as four isoforms produced by alternative splicing and is encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

保存缓冲液

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol 

运输条件

2-8°C 

靶点 Uniprot 登记号

Q8IYH5 

靶点基因 ID

26009 

靶点全称

zinc finger, ZZ-type containing 3 

靶点别名

ATAC1 

靶点研究领域

Epigenetics and Nuclear Signaling 

亚型
Immunogen-specific rabbit IgG 

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ab102230(ZZZ3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)...

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