Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.
 

Research Field

Cardiovascular
 

Product Categories

Protein
 

Host

E-coli
 

Application

Functional Assay
 

Purification

Affinity Purified
 

Conjugation

Unconjugated
 

Modification

His
 

Form

lyophilized
 

Buffer System

0.01M PBS, pH 7.2
 

Storage

Aliquot and store at -80°C for long term. Avoid freeze/thaw cycles.

SDS-PAGE analysis of recombinant Mouse VEGF165....